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Asian Pharmaceuticals

Triad 10mg Tab

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TRIAD 10mg Tab is an effective medicine used for the prevention of migraine attacks. It can also be used to treat neuropathic pain (nerve pain that may be caused by nerve damage or chronic diseases such as diabetes) in adults. It is also used to treat depression in adult patients.

 

Indications:

  • Relief of depression
  • Unlabeled uses: Management of chronic pain associated with migraine, tension headache, phantom limb pain, diabetic neuropathy, peripheral neuropathy, cancer or arthritis; treatment of panic and eating disorders.

Dosage:

  • ADULTSOUTPATIENTS: PO 75 to 150 mg/day in divided doses; give in evening or at bedtime because of sedative effects.
                     HOSPITALIZED PATIENTS: PO 100 to 300 mg/day.
  • ADOLESCENT & ELDERLY PATIENTS: PO 10 mg tid and 20 mg at bedtime.
  • MAINTENANCE: PO 40 to 100 mg/day.
  • PARENTERAL FORM: Do not use IV route. IM 20 to 30 mg qid. Change to oral dosing as soon as possible.

Onset of Action: The effect of this medicine can be observed within 3-6 weeks of administration.

Duration of Action: The effect of this medicine lasts for an average duration of 4- 7 weeks after onset of action.

 

Side Effects:

  • Headache
  • Nausea and Vomiting
  • Constipation or diarrhea
  • Blurred vision
  • Swelling of face, lips, eyelids, tongue, hands and feet
  • Unexpected weight gain or loss
  • Chest pain and discomfort
  • Shortness of breath
  • Weakness in one side of the body
  • Slurred speech
  • Seizures
  • Decreased sexual urge
  • Unusual bleeding

Interactions:

  1. Interaction with Medicines: Severe interactions with cisapride ,clozapine ,fluoxetine ,linezolid ,ondansteron ,selegeline ,phenylephrine.
  2. Interaction with Diseases:
    Heart Disease: This medicine should be used with caution in patients suffering from heart disease like heart failure, stroke, heart block etc. A fall in blood pressure, changes in the pulse, dizziness and other associated complications should be reported to the doctor. It is advised to not take this medicine if the patient has recently suffered a heart attack.
    Pheochromocytoma: This medicine should be administered with extreme caution in patients suffering from pheochromocytoma. The risk of severe to fatal change in blood pressure is very high. Suitable dose adjustment and clinical monitoring of the symptoms is recommended in such cases.
    Seizure disorders: This medicine should be used with caution in patients having a seizure disorder. Seizures may be caused due to a disease, some other medicine, head injury in the past etc. Using this medicine can cause more frequent and severe episodes of seizures.
    Diabetes: This medicine should be used with caution if you have diabetes as the risk of changes in blood sugar levels are very high. You should get your blood sugar levels checked more frequently while using this medicine.
    Glaucoma: This medicine should be used with caution if you have glaucoma. Use of this medicine can worsen the symptoms of both closed and open-angle glaucoma.

 

Contraindications:

  • Hypersensitivity to any tricyclic antidepressant
  • Use during acute recovery phase of MI
  • Concomitant use with monoamine oxidase (MAO) inhibitors, guanethidine or similarly active compounds.

Warnings:

  • Sedation: Use of this medicine can cause moderate to severe sedation and impairment of physical abilities. You should avoid work that requires a high level of mental alertness while using this medicine.
  • Hypotension: This medicine should be used with the caution due to the risk of sudden fall in blood pressure.
  • Liver disease: This medicine should be used with caution if you are suffering from impaired liver functioning. Report all such conditions to the doctor before receiving this medicine.
  • Kidney disease: This medicine should be used with caution if you are suffering from impaired kidney function. Report all such conditions to the doctor before receiving this medicine.
  • Bipolar disorder: This medicine should be used with extreme caution in patients suffering from bipolar disorder. Symptoms of mania and depression can worsen upon usage of this medicine. Consult your doctor and report the incidence of bipolar depression or mania before receiving this medicine.
  • Suicidal tendencies: Use of this medicine is reported to provoke suicidal thoughts and increased suicidal tendencies, especially in young patients. Report any such incidence to the doctor so that counseling and monitoring of progress can be performed at regular intervals.
  • Benign prostatic hyperplasia: This medicine should be used with caution if you have an enlarged prostate gland. The symptoms might worsen after using this medicine.
  • Withdrawal symptoms: The use of this medicine should not be discontinued abruptly. You may experience withdrawal symptoms especially if you have been using a high dose for a long duration. Do not stop the use of this medicine without consulting your doctor.
  • Surgery: Use of this medicine is not recommended if you are planning to undergo a surgery in near future. Consult your doctor in this regard so that it can be discontinued properly.
  • Pregnancy: This medicine should be used by pregnant women only when the benefits outweigh the risk associated with usage. This medicine can cause harmful effects on fetus. Hence, you are advised to consult your doctor before taking this medicine.
  • Lactation: This medicine should not be used by women who are breastfeeding. If it is absolutely necessary to take this medicine then you should stop breastfeeding. Consult your doctor before using this medicine.
  • Safety with alcohol: You should restrict or minimize the use of alcohol while taking this medicine. Symptoms like sleepiness, excessive sweating, muscle stiffness and change in pulse should be reported to the doctor on priority.

General Instructions:

  • Take this medicine as instructed by the doctor.
  • Follow all the labeled instructions while taking this medicine.
  • Ensure that the right quantity of medicine is consumed for the prescribed duration only.
  • Initial use may worsen the symptoms of depression and it may take up to 20-30 days for any improvement to happen.
  • Usage should not be stopped abruptly.

Storage Conditions:

  • Store at room temperature, under 77°F (25ºC).
  • Keep it away from high temperatures.

Substitutes:

Disclaimer
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of the physician or other qualified health provider with any question you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.
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