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Uni-pharma Kleon Tsetis

T4 25mcg Tab

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Product Details

T4 25MCG TAB is a synthetic hormone similar to the one produced by the thyroid gland. It is primarily used to treat hypothyroidism, a condition where the thyroid gland does not produce sufficient quantities of hormones. It is also used to treat certain other disorders associated with the thyroid gland.

 

Indications:

  • Hypothyroidism
  • Thyroid cancer
  • Myxedema coma
  • Organ preservation in brain-dead organ donors

Dosage:

  • Mild Hypothyroidism: 100-125 mcg PO qDay; not to exceed 300 mcg/day
  • Severe hypothyroidism: Initial: 12.5-25 mcg PO qDay, adjust dose by 25 mcg/day q2-4 weeks PRN.
  • Myxedema coma: 300-500 mcg IV once, then 50-100 mcg qDay until patient is able to tolerate oral administration.

Onset of action: The effect of this medicine can be observed within 3-5 days of oral administration.

Duration of action: The time duration for which this medicine remains effective in the body is subject to vary based on the thyroid hormone levels.

 

Side effects:

  • Changes in menstrual cycle
  • Temporary hair loss
  • Chest pain and discomfort
  • Rapid or irregular heartbeat
  • Thyrotoxic crisis

Interactions:

  1. Interaction with Medicines: Severe to moderate interactions with Carbamazepine, Phenytoin, Warfarin, Ethinyl Estradiol, Rifampicin, Epinephrine, Phenobarbital, Insulin and other anti diabetic medicines, Ketamine, Testosterone, Amphetamine, Antacids containing calcium/magnesium/aluminum.
  2. Interaction with Diseases:
    Cardiovascular disease: This medicine should be used with caution in patients having a disease of the heart and the blood vessels. Treatment should be initiated at the lowest possible dose with frequent monitoring of cardiovascular functions. If the symptoms of the heart disease worsen, then appropriate dose reductions should be done on priority.
    Diabetes: This medicine should be used with caution in patients having diabetes or any other endocrine disorder due to the increased risk of worsening of the condition of the patient. Appropriate dose adjustments and clinical monitoring are advised during treatment with this medicine. The dose of insulin or other anti-diabetic medicines should be adjusted appropriately both during treatment with Levo-Thyroxine and while discontinuing therapy with Levo-Thyroxine.
  3. Interaction with Foods: Food items containing calcium may reduce the effects of this medicine if both are taken together. There should be a minimum time gap of 4 hours between the consumption of these food items and Levo-Thyroxine.

 

Contraindications:

  • Allergy: This medicine is not recommended for use if you have a known allergy to levothyroxine, thyroid hormone, or any other ingredients present with it.
  • Thyrotoxicosis: This medicine is not recommended for use if you have an excess of thyroid hormone in the body due to overactive glands or hyperthyroidism.
  • Adrenal insufficiency: This medicine is not recommended for use in patients with an untreated condition where the adrenal glands do not produce steroid hormones in adequate quantities (adrenal insufficiency). Therapy with this medicine in such patients could lead to worsening of the condition of the patient.
  • Acute myocardial infarction: This medicine is not recommended for use if you have recently had an episode of a heart attack.

Warnings:

  • Thyroid nodules: This medicine should be used with extreme caution in patients with thyroid nodules. Its use is contraindicated if the serum TSH level is already suppressed.
  • Use in postmenopausal women: This medicine is not recommended for use in postmenopausal women with osteoporosis, heart disease, or any other systemic illness. Long-term use of this medicine may cause a decrease in bone mineral density, which may increase the risk of fractures.
  • Treatment of obesity: This medicine should not be used for the treatment of obesity, especially in patients with normal thyroid hormone levels.
  • Treatment of infertility: This medicine should not be used for the treatment of male/female infertility unless associated with low thyroid hormone levels.
  • Dose adjsutments: Appropriate dose adjustments should be done based on the patient's disease profile, use of other medicines, food habits, and other parameters. Underdosing or overdosing may lead to severe side effects.
  • Change of brands: It is advised to consult a doctor or a trained healthcare professional before switching from one brand of this medicine to another. Use of different formulations may cause undesired side effects.
  • Use in elderly: This medicine should be used with caution in the elderly population since the risk of side effects are significantly high.
  • Pregnancy: This medicine is safe for use during pregnancy. Consult your doctor before taking this medicine.
  • Lactation: This medicine is safe for use while breastfeeding. Consult your doctor before taking this medicine.
  • Safety with alcohol: Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.

General instructions:

  • Take Levo-Thyroxine exactly as prescribed by the doctor.
  • Do not take in larger or smaller quantities than recommended.
  • Your dose is likely to change over the course of treatment based on the response and tolerance.
  • It may take several weeks before this medicine starts to show its effect.
  • Do not stop the use of this medicine even when the symptoms resolve or improve unless instructed by the doctor.

Storage Conditions:

  • Store at room temperature, under 77°F (25ºC).
  • Keep it away from high temperatures.

Substitutes:

  • EL THYRO 25MCG TAB
  • THYROLAR 25MCG TAB
Disclaimer
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of the physician or other qualified health provider with any question you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.
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