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Methapred 16mg Tab

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Product Details

METHAPRED 16MG TAB is used to treat conditions such as arthritis, blood disorders, severe allergic reactions, certain cancers, eye conditions, skin/kidney/intestinal/lung diseases, and immune system disorders. It decreases your immune system's response to various diseases to reduce symptoms such as swelling, pain, and allergic-type reactions. This medication is a corticosteroid hormone.

 

Indications:

  • Allergic Conditions
  • Acute Exacerbations of Multiple Sclerosis
  • Pneumocystis (carinii) jiroveci Pneumonia in AIDS Patients (Off-label)
  • Acute Spinal Cord Injury (Off-label)
  • Severe Lupus Nephritis (Off-label)

Dosage:

  • Allergic Conditions:
    Day 1: 8 mg PO before breakfast, 4 mg after lunch and after dinner, and 8 mg at bedtime
    Day 2: 4 mg PO before breakfast, after lunch, and after dinner and 8 mg at bedtime
    Day 3: 4 mg PO before breakfast, after lunch, after dinner, and at bedtime
    Day 4: 4 mg PO before breakfast, after lunch, and at bedtime
    Day 5: 4 mg PO before breakfast and at bedtime
    Day 6: 4 mg PO before breakfast
    May be tapered over 12 days (to decrease chance of dermatitis flareup).
  • Acute Exacerbations of Multiple Sclerosis: 160 mg IV once daily for 1 week, then 64 mg IV every other day for 1 month.

  • Pneumocystis (carinii) jiroveci Pneumonia in AIDS Patients (Off-label): 30 mg IV q12hr for 5 days, then 30 mg IV q24hr for 5 days, then 15 mg IV q24hr for 11 days.

  • Acute Spinal Cord Injury (Off-label): 1st hour: 30 mg/kg IV over 15 minutes, next 23 hours: 5.4 mg/kg/hr IV by continuous infusion.

  • Severe Lupus Nephritis (Off-label): 0.5-1 g IV over 1 hour once daily for 3 days.

Side effects:

  • Acne
  • Adrenal suppression
  • Amenorrhea
  • Delayed wound healing
  • Delirium
  • Diabetes mellitus
  • Edema
  • Emotional instability
  • Erythema
  • Fluid retention

Interactions:

Severe to moderate interactions with mifepristone, anthrax vaccine, apalutamide, BCG vaccine live, carbamazepine, cisapride, clarithromycin.

 

Contraindications:

  • Untreated serious infections
  • Documented hypersensitivity to drug or components (eg, lactose monohydrate from cow milk)
  • Intrathecal administration
  • Systemic fungal infection (except intra-articular injection in localized joint conditions)
  • IM route is contraindicated in idiopathic thrombocytopenic purpura
  • Premature infants (formulations containing benzyl alcohol only)
  • Traumatic brain injury (high doses)
  • Administration of live or live, attenuated vaccines is contraindicated in patients receiving immunosuppressive doses of corticosteroids.

Warnings:

  • Use with caution in cirrhosis, ocular herpes simplex, hypertension, diverticulitis, hypothyroidism, myasthenia gravis, peptic ulcer disease, osteoporosis, ulcerative colitis, psychotic tendencies, renal insufficiency, pregnancy, diabetes mellitus, history of seizure disorders, multiple sclerosis, thromboembolic disorders, myocardial infarction.
  • Pregnancy: Generally not recommended, so use only if needed after consultation with physician.
  • Lactation: Drug enters milk; use with caution after consultation with physician.

General instructions:

  • Take tablet as prescribed by physician.
  • Do not take in larger amounts than advised.
  • Inform the doctor if you experience any undesirable effects.

Storage conditions:

  • Store between 15°C-30°C.
  • Do not freeze.
  • Protect from sunlight and moisture.
Disclaimer
The contents of this website are for informational purposes only and not intended to be a substitute for professional medical advice, diagnosis, or treatment. Please seek the advice of the physician or other qualified health provider with any question you may have regarding a medical condition. Do not disregard professional medical advice or delay in seeking it because of something you have read on this website.
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